Enclomiphene Citrate for Testosterone Optimisation: Evidence, Dosage, and Protocol

Evidence Level: Strong (multiple clinical trials)

Enclomiphene Citrate raises endogenous testosterone by blocking hypothalamic estrogen receptors, which increases LH and FSH output. Multiple clinical trials have shown significant testosterone increases in men with secondary hypogonadism. Unlike exogenous testosterone (TRT), Enclomiphene preserves fertility and endogenous production.

Mechanism: How Enclomiphene Citrate Affects Testosterone Optimisation

For testosterone optimisation, Enclomiphene’s action at the hypothalamic estrogen receptors is central. By blocking E2 feedback, the hypothalamus increases GnRH pulse frequency, which drives the pituitary to release more LH and FSH. The Leydig cells in the testes respond to elevated LH by producing more testosterone.

Dosage Protocol for Testosterone Optimisation

For testosterone optimisation, research protocols typically use 6.25 to 25 mg per day. Blood work should be checked at baseline, 4 weeks, and 8 weeks (total testosterone, free testosterone, LH, FSH, estradiol, SHBG).

How to Source Enclomiphene Citrate in Canada

Elite Bio Supply carries pharmaceutical-grade Enclomiphene (50 mg tablets, 5-count) with domestic shipping across Canada via Canada Post. All products are third-party tested for purity and identity. View Enclomiphene product page and order.

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