Clomid (Clomiphene Citrate) for Secondary Hypogonadism: Evidence, Dosage, and Protocol

Evidence Level: Strong (multiple clinical trials)

Secondary hypogonadism is characterised by low testosterone with low or inappropriately normal LH and FSH, indicating a pituitary or hypothalamic cause rather than testicular failure. Clomid (Clomiphene Citrate) directly addresses this by stimulating the hypothalamus to increase gonadotropin output. Multiple trials have shown normalisation of testosterone levels in men with secondary hypogonadism.

Mechanism: How Clomid (Clomiphene Citrate) Affects Secondary Hypogonadism

In secondary hypogonadism, the problem is insufficient GnRH signalling. {Name_short} overcomes this by blocking the estrogen-mediated negative feedback that suppresses GnRH. This is why Clomid works for secondary hypogonadism but not primary (where the testes themselves are the problem).

Dosage Protocol for Secondary Hypogonadism

For secondary hypogonadism, 25 is the typical starting dose. Monitor total testosterone, free testosterone, LH, FSH, and estradiol at baseline, 4 weeks, and every 3 months. The goal is testosterone normalisation (>300 ng/dL) while maintaining acceptable estradiol levels.

How to Source Clomid (Clomiphene Citrate) in Canada

Elite Bio Supply carries pharmaceutical-grade Clomid (100 mg tablets, 30-count) with domestic shipping across Canada via Canada Post. All products are third-party tested for purity and identity. View Clomid product page and order.

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