What Is hCG (Human Chorionic Gonadotropin)?
Human chorionic gonadotropin (hCG) is a peptide hormone that mimics luteinizing hormone (LH) and directly stimulates the Leydig cells in the testes to produce testosterone. It is used in men for testosterone optimization, fertility preservation during TRT, and post-cycle therapy. Unlike SERMs like Clomid and enclomiphene, which work indirectly by raising LH, hCG acts directly on the testes.
How hCG (Human Chorionic Gonadotropin) Works
hCG binds to LH receptors on Leydig cells, triggering the same intracellular cascade as endogenous LH: cAMP activation, cholesterol transport to mitochondria, and conversion to testosterone via the steroidogenic pathway. Because hCG acts directly on the testes, it works even when the HPG axis is suppressed (e.g., during TRT). This makes it the go-to compound for maintaining testicular function and intratesticular testosterone (ITT) during exogenous testosterone use.
hCG (Human Chorionic Gonadotropin) Dosage
For TRT adjunct (fertility preservation): 500 to 1,000 IU subcutaneously 2 to 3 times per week. For PCT: 1,500 to 2,000 IU every other day for 2 to 3 weeks, followed by SERM therapy. For monotherapy testosterone optimization: 1,500 to 3,000 IU twice weekly. Requires injection (subcutaneous or intramuscular) and refrigeration.
Clinical Evidence
hCG is well-studied for male fertility. A 2005 study in the Journal of Clinical Endocrinology and Metabolism showed that adding hCG to TRT maintained intratesticular testosterone and spermatogenesis. A 2013 Fertility and Sterility review confirmed hCG preserves sperm production when used alongside TRT. For testosterone monotherapy, studies show reliable increases but with the need for regular injections and monitoring for estradiol elevation (hCG can increase aromatase activity).
hCG (Human Chorionic Gonadotropin) vs Clomid: How They Compare
hCG and Clomid both raise testosterone and preserve fertility, but through different mechanisms. hCG acts directly on the testes (mimics LH), while Clomid acts on the hypothalamus (blocks estrogen, raises endogenous LH). Key differences: hCG requires injection and refrigeration; Clomid is an oral tablet. hCG works even with a suppressed HPG axis (e.g., during TRT); Clomid requires a functional HPG axis. hCG can raise estradiol more significantly (via aromatase); Clomid blocks estrogen receptors. For men who want an oral, non-injection approach to testosterone optimization and fertility, Clomid or enclomiphene are the preferred options. Elite Bio Supply carries both.
Legal Status in Canada
hCG is a prescription drug in Canada and a controlled substance in some jurisdictions for anti-doping purposes. It requires a prescription and medical supervision.
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Elite Bio Supply sells research compounds for research purposes only. This content does not constitute medical advice. The information above is based on published clinical literature and is provided for informational purposes. Consult a qualified physician before starting any protocol.