What Is Oxiracetam?
Oxiracetam is a synthetic racetam nootropic that is 3 to 5 times more potent than piracetam by weight. Developed in the 1970s, it is notable for its mild stimulatory properties, which distinguish it from the more subtle cognitive effects of piracetam. Oxiracetam is prescribed in Italy (as Neuromet) and some other European countries for cognitive impairment.
How Oxiracetam Works
Oxiracetam modulates AMPA receptors and enhances cholinergic neurotransmission, similar to piracetam. Additionally, it increases D-aspartate release in the hippocampus, which supports NMDA receptor activation and long-term potentiation (LTP), the cellular mechanism underlying memory formation. This glutamatergic enhancement likely explains its mild stimulatory effect, which users describe as increased mental energy without the jitteriness of caffeine.
Oxiracetam Dosage
Standard research dose: 800 to 2,400 mg per day, divided into 2 to 3 doses. Water-soluble, can be taken with or without food. Choline co-supplementation recommended. Half-life: 8 to 10 hours.
Clinical Evidence
A 1997 study in Psychopharmacology found oxiracetam improved logical performance and attention in healthy volunteers. Italian clinical trials in elderly patients with dementia showed improvements in memory and cognitive function scores. A comparative study found oxiracetam superior to piracetam for certain logical reasoning tasks. However, the overall clinical evidence base is smaller than piracetam, with fewer large-scale RCTs.
Oxiracetam vs Piracetam: How They Compare
Oxiracetam and piracetam are both water-soluble racetams with similar core mechanisms (AMPA modulation, cholinergic enhancement). Oxiracetam adds mild stimulatory properties through D-aspartate and NMDA receptor effects, making it better suited for tasks requiring sustained focus and logical reasoning. Piracetam has the larger evidence base, longer track record, and broader cognitive profile (verbal fluency, memory, cerebral blood flow). For researchers wanting the foundational racetam with the most clinical data, piracetam is the starting point.
Legal Status in Canada
Oxiracetam is not a controlled substance in Canada. It is not scheduled under the CDSA and is available for research purposes.
Related Resources
- Piracetam Dosage Guide
- Piracetam Side Effects
- Buy Piracetam in Canada
- The Complete Guide to Racetam Nootropics
Explore More About Piracetam
Order Piracetam (1200 mg tablets, 100-count)
Shipped from Canada. Discreet packaging. 350+ cryptocurrencies accepted.
Elite Bio Supply sells research compounds for research purposes only. This content does not constitute medical advice. The information above is based on published clinical literature and is provided for informational purposes. Consult a qualified physician before starting any protocol.