Quick Facts
Enclomiphene citrate 25 mg is the purified trans-isomer of clomiphene citrate, a selective estrogen receptor modulator (SERM) used in men’s health research for testosterone restoration and fertility preservation. Unlike racemic clomiphene (Clomid), enclomiphene contains only the therapeutically active isomer, avoiding the estrogenic effects of zuclomiphene. Clinical studies show enclomiphene restores testosterone to the normal physiological range (450-600 ng/dL) while maintaining sperm parameters.
- Active compound: Enclomiphene Citrate 25 mg per tablet
- Pack size: 50 tablets (5 x 10 sealed blister packs)
- CAS number: 7599-79-3
- Primary applications: Testosterone restoration, fertility preservation, hormonal research
- Fulfilment: Ships from Canada. Crypto payments accepted (350+ cryptocurrencies).
Enclomiphene Citrate 25 mg Tablets
Enclomiphene citrate is the purified trans-isomer of clomiphene, isolated from the racemic mixture found in conventional Clomid. While standard clomiphene contains both enclomiphene (trans) and zuclomiphene (cis) isomers, this product provides only the enclomiphene isomer, which is responsible for the desired anti-estrogenic and gonadotropin-stimulating effects.
How Enclomiphene Differs from Clomid
Standard clomiphene (Clomid) is a racemic mixture containing approximately 62% zuclomiphene and 38% enclomiphene. Zuclomiphene, the cis-isomer, has a longer half-life and accumulates in the body over time, producing estrogenic (agonist) effects that can counteract the therapeutic benefits. Enclomiphene isolates the trans-isomer only, providing cleaner receptor antagonism at the hypothalamus and pituitary without the estrogenic carryover.
Mechanism of Action
Enclomiphene acts as a selective estrogen receptor antagonist at the hypothalamus and pituitary gland. By blocking estrogen’s negative feedback on these structures, it increases pulsatile release of gonadotropin-releasing hormone (GnRH), which in turn stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion. This leads to increased endogenous testosterone production while preserving spermatogenesis.
Common Research Applications
- Testosterone restoration in secondary hypogonadism research
- Fertility preservation studies (maintains sperm production)
- Hormonal signalling pathway investigations
- SERM receptor binding and selectivity research
- Post-cycle therapy (PCT) protocol studies
Product Details
- Active ingredient: Enclomiphene Citrate (trans-clomiphene citrate)
- Strength: 25 mg per tablet
- Quantity: 50 tablets (5 x 10 blister packs)
- Form: Oral tablets
- Packaging: Sealed blister packs with labelled cartons
- Molecular formula: C₂₆H₂₈ClNO (free base)
- CAS number: 7599-79-3
Shipping and Availability
This product is shipped from Canada and fulfilled domestically for Canadian customers. All orders ship in discreet, unmarked packaging via Canada Post with full tracking. We accept over 350 cryptocurrencies for secure, private transactions.
Important Notice
This product is sold as labelled for research purposes. Information provided is for educational purposes only.
Frequently Asked Questions
What is the difference between enclomiphene and Clomid?
Clomid (clomiphene citrate) is a racemic mixture of two isomers: enclomiphene (trans) and zuclomiphene (cis). Enclomiphene citrate contains only the purified trans-isomer, which is the therapeutically active component responsible for stimulating testosterone production. It avoids the estrogenic effects associated with the zuclomiphene isomer.
Why do researchers prefer enclomiphene over clomiphene?
Enclomiphene offers a cleaner pharmacological profile. The zuclomiphene isomer in standard Clomid has a longer half-life and accumulates over time, producing estrogenic effects. Enclomiphene provides more predictable pharmacokinetics and targeted receptor antagonism without this estrogenic carryover.
What is the half-life of enclomiphene?
Enclomiphene has a serum elimination half-life of approximately 5 to 10 hours. Peak serum concentrations are reached 2 to 3 hours after oral administration.
How many tablets are included?
Each package contains 50 tablets supplied in sealed blister packs (5 strips of 10).
Is this shipped from Canada?
Yes. Orders are fulfilled and shipped from within Canada via Canada Post with tracking included.
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